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KMID : 0380919870160040262
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Journal of the Korean Society of Food Nutrition
1987 Volume.16 No. 4 p.262 ~ p.267
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The Effect of Schizandrae fructus Extract on Blood Constituents of Alloxan - Induced Diabetic Rabbits
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서화중/Sheo HJ
이명열/황경숙/Lee MY/Hwang GS
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Abstract
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The effect of Schizandrae fructus extract (S. F. E.) on experimentallly alloxan-induced diabetes in rabbits and the acute toxicity on mice were studied;
LD_(50) of the extract was 2l.50g/㎏ by intraperitoneal administration in mice.
S. F. E. showed more rapid recovering effect than the control group; all samples showed excellent effect of lowering the hyperglycemia, that is, the blood glucose level was significantly decreased by 800㎎/㎏ in 2 days and by 200㎎/㎏ in 6 days.
SGPT activity was lowered promptly after 4 days in 800㎎/㎏.
Total cholesterol level was not shown significant lowering effect by 200㎎/㎏, but rapid by 800㎎/㎏, in 6 days; blood urea nitrogen level was decreased gradually in 800㎎/㎏ after 10 days and 14 days in 200㎎/㎏.
In histological studies of pancreas, the sample groups exhibited less karyorrhexis, vacuolar and vesicular change, more stable in contents of β-cells than the control group.
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